FIRST-line support for Assistance in Breathing in Children (FIRST-ABC)

Short title:


Chief Investigator:

Dr Padmanabhan Ramnarayan


Great Ormond Street Hospital for Children NHS Foundation Trust


National Institute for Health Research (NIHR)

Lay Summary:

Even though respiratory support is a common intervention in paediatric critical care, there is no randomised controlled trial (RCT) evidence regarding the effectiveness of two commonly used modes of non-invasive respiratory support (NRS), continuous positive airway pressure (CPAP) and high-flow nasal cannula therapy (HFNC). FIRST-line support for assistance in breathing in children is a master protocol of two pragmatic non-inferiority RCTs to evaluate the clinical and cost-effectiveness of HFNC (compared with CPAP) as the first-line mode of support in critically ill children.

Project Website:

Associated Publications:

Pub Med, 2022:

Bmj open, 2022: