Long title:
The Infant KIdney Dialysis and Utrafiltration (I-KID) Study: A Stepped-Wedge Cluster-Randomized Study in Infants, Comparing Peritoneal Dialysis, Continuous Venovenous Hemofiltration, and Newcastle Infant Dialysis Ultrafiltration System, a Novel Infant Hemodialysis Device
Short title:
I-KID
Chief Investigator:
Dr Heather Lambert
Co-Investigators:
Associate Professor John Pappachan, Dr Claire Westrope, Dr Daljit Hothi, Dr David Grant, Dr Jon Smith, Dr Lucy Wirz, Dr Malcolm Coulthard, Dr Quen Mok, Dr Rachel Agbeko, Dr Roger Parslow, Honorary Professor Kevin Morris, Mr Chris Boucher, Mrs Jean Crosier, Professor Elaine McColl, Professor John Matthews
Organisation:
Newcastle Upon Tyne Hospitals NHS Foundation Trust & Newcastle Clinical Trials Unit
Funder:
NIHR – Efficacy and Mechanism Evaluation Programme (EME)
Lay Summary:
Renal replacement therapy (RRT) options are limited for small babies because of lack of available technology. We investigated the precision of ultrafiltration, biochemical clearances, clinical efficacy, outcomes, and safety profile for a novel non-Conformité Européenne-marked hemodialysis device for babies under 8kg, the Newcastle Infant Dialysis Ultrafiltration System (NIDUS), compared with the current options of peritoneal dialysis (PD) or continuous venovenous hemofiltration (CVVH).
Project Website:
https://research.ncl.ac.uk/i-kid